-
New surfactants forming anisotropic micelles and microemulsions in CO2
An analogue of the popular surfactant AOT with isopropyl glycol tails (IG-AOT, Figure.1) has been recently designed as a co-surfactant for water-in-CO2 (w/c) systems: stable... -
Nanosuspsomicroemulsions: nanosuspension stabilty
At Kings College London we have recently developed a novel combination formulation, a nanosuspsomicroemulsion (NSME), comprising of a microemulsion (ME) containing one drug and... -
Temperature and flow stability of model sodium alkylbenzene sulfonate (NaLAS)...
Linear sodium alkylbenzene sulfonate (NaLAS) is one of the most extensively used anionic surfactant in the world, mainly as a biodegradable laundry detergent, with an annual... -
Curvature effects in polyelectrolyte-surfactant solution interactions
This proposal continues our investigations into polyelectrolyte-surfactant solutions which form thin films at the air-solution interface. Our previous work has investigated the... -
Structural origin of anomalous relaxation behaviour in alcohol-water mixtures
In recent dielectric and calorimetric studies of some alcohol-water mixtures we have discovered unexpected and unexplained relaxation behaviours. Our aim with this proposal is... -
Anion effects on self-assembly in deep eutectic solvents.
Deep Eutectic Solvents (DES) are mixtures of an organic salt with a hydrogen bond donor that form strong interactions which hinder crystallisation. DES share many features with... -
The effect of alcohol chain length on the interaction between PS-PEO copolyme...
In many applications, surfactants are formulated with a variety of additives to achieve a desired range of properties; polymers and cosurfactants/cosolvents (such as alcohols)... -
Mixed surfactants for dialable organogels
The idea is to be able to ¿dial-up¿ the length and properties of CO2-philic and organo-philic rod-like micelles. This proposal aims to explore mixed surfactant systems in... -
Effect of reversing lipid head group charge on vesicular properties
Zwitterionic lipids such as phosphatidylcholine (PC) are major components of the membranes that compartmentalize organisms. Although there is a large literature on PC, cationic... -
Structure and gelation of poloxamer based hydrogels for injectable drug delivery
We seek to develop hydrogel formulations for injectable controlled drug delivery from Pluronics to enhance patient compliance, decrease side effects and reduce dose and... -
Structure of hyaluronic acid solutions from dilute to concentrated regime
Hyaluronic Acid (HA) is a biopolymer naturally occurring in many biological systems, including the human body with vital roles in the eye, skin and joints due to its unique... -
A SANS study of nano-gels with a temperature tunable bio-interface
Hyaluronic acid (HA) plays a key role in tumour cell bio-adhesion and, as such, this interaction opens up possibilities for targeted tumour pathologies We have created a... -
Structure of chain-grafted silica nanoparticles
The aim of the proposed experiment is to carry out a series of SANS measurements on chain-grafted silica nanoparticles prepared in our laboratory. In this experiment we plan to... -
Structure of Cellulose Nanofibril Gels
This proposal is part of a new project based on understanding the formation of gels in suspensions of partially oxidised cellulose nanofibrils with small amounts of salt or... -
SANS studies of phospholipid:sterol vesicles and the membrane interactions of...
The increasing incidence of pathogenic fungi resistant to treatment with amphotericin B (AmB) has created a demand for novel anti-fungal agents that can circumvent the... -
FRET-based Conjugated Polymer Macromolecular Switch for Bio-Anion Recognition
We intend to study the aggregation behaviour of the all-conjugated block catiocopolyelectrolyte PF2/6-P3MAHT in the presence of the biomacroanion guanosine triphosphate (GTP) in... -
Adsorption of of hydrophobin and hydrophobin / surfactant mixtures at the oil...
Hydrophobins are secreted fungal proteins and are small lipopeptide biosurfactants. They are strongly surface active and self-assemble at interface, and these unique film... -
Compartmentalised Supramolecular Structures through CB[8]-mediated Hierarchic...
We have recently developed a method to prepare a wide variety of amphiphilic diblock copolymers through a supramolecular linkage that is stable in water. This has been achieved... -
Small-Angle Neutron Scattering studies of a bacterial colonization factor
We plan to carry out SANS experiments on a bacterial colonization factor to elucidate how it interacts with chitin, which is found on the surface of plankton and crustaceans.... -
Effect of pH on the shape of oil-in-water microemulsions formed by a zwitteri...
Despite interest in microemulsions as drug delivery vehicles, there is a lack of structural understanding to justify the formulations used. The present study examines the use of...