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Characterisation of self-assembly in cationic-oligoanion mixtures: from micel...
The proposal is part of an EPSRC funded programme (EP/GR065705) on surfactant multilayer structures, and involves the interaction between ionic surfactants and oligoions. It... -
Encapsulation of perfume actives with biodegradable amphiphilic graft copolymers
Amphiphilic non-linear graft copolymers formed by biocompatible blocks are attractive candidates for the encapsulation of actives in several applications, such as drug delivery,... -
Interactions between phenylboronic acid modified polyacrylamides and surfactants
We are currently investigating phenylboronic acid modified polyacrylamides with variable phenylboronic acid block lengths as a route to glucose sensors with controllable... -
Impact of homo- and hetero-association of complex molecular nano-sized drug d...
The present proposal concerns a PEGylated, hydrophobic drug containing polylysine dendrimer that demonstrates unexplained batch-to-batch variability in that two batches of the... -
Solubilisation of Drug Molecules in Nonionic Surfactant Micelles: Structural ...
This proposal aims to understand how the structure of non-ionic surfactant micelles affects the amount of fungicides solubilised. SANS is a technique unique for unravelling the... -
Structure of Cellulose Nanofibril Gels with Alcohols
Our group has been working partially oxidized cellulose nanofibrils which form gels in aqueous formulations. Recently we have observed that these fibrils also gel when dialysed... -
Structure of Colloidal Titania Particles in Water vs Organic Solvent
Dye sensitised solar cells, based around colloids of the wide bandgap semiconductor TiO2 with bound dyes have potential to provide a cheap,sustainable source of solar energy... -
Characterisation and peptide resistance capabilities of bacterial membrane mi...
Lysylphosphatidylglycerol (LPG) is a major constituent of the plasma membrane of the bacterial pathogen methicilin resistant Staphylococcus aureus (MRSA), which has been... -
AOT stabilized aqueous ferrofluids
The aim of the experiment is to employ SANS to study the physical properties of a novel and very stable aqueous Fe3O4 ferrofluid system stabilized by the commercially available... -
Rhamnolipids and Amphotericin B: a potential highly specific delivery system ...
Rhamnolipids are a type of glycolipid biosurfactant, produced as secondary metabolites by various Pseudomonas and Burkholderia species; they have been shown to possess... -
The effect of unsaturation on the shear dependence of cationic lamellar phase...
Products such as fabric and hair conditioners are commonly in the form of di-alkyl chain cationic lamellar phase dispersion. The effects of shear on such lamellar phase... -
Solution aggregation of short peptide amphiphiles
Short peptide sequences consisting of hydrophobic and hydrophilic amino acid units are capable of self-assembly to lead to interfacial adsorption and solution nano-aggregation.... -
interaction of a pharmaceutical water-soluble polymer with bio-relevant surfa...
We have been developing hydroxypropylmethyl cellulose (HPMC) microspheres for delivering poorly water-soluble drugs. The in vitro dissolution data showed that the presence of... -
Mixed micelles with green surfactants
This proposal aims to explore aqueous phase structures and compositions of a series of mixed surfactants. Although standard petrochemically-derived surfactant mixtures have been... -
Constructing analogues of gemini and oligomeric surfactants through noncovale...
Gemini-like and oligomeric-like surfactants can be constructed by single-chain or gemini surfacants with connecting molecules through noncovalent binding without complicated... -
Gelatin scaffolds from marine species: Physical gels and enzymatically cross-...
Hydrogels from biopolymers are attracting increasing attention for a range of biomedical applications, but the lack of structural understanding hinders the development of new... -
Protein-decorated superparamagnetic iron oxide nanoparticles
The aim of this research is to understand the structural confirmation of dextran coated iron oxide (Fe3O4) nanoparticles in the presence of Bovine serum albumin (BSA) in aqueous... -
Kinetic Study of the Mechanistic Complexation Process Between DNA and Cationi...
We propose to use the new SANS2d to study the dynamic structural evolution in the couse of the formation of DNA-cationic polymer complexes. The dynamic process and the mixing... -
AGGREGATION BEHAVIOUR OF A NOVEL P-AOT SURFACTANT
This proposal aims to provide essential surfactant micellisation structural information of significant interest in its own right but also as key information for our on-going... -
Mechanism and rates of phospholipid exchange and flip-flop under physiologica...
Variation in lipid composition between different biological membrane and across membranes are vital for a wide range of cellular functions. Significant differences in lipid...