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Characterisation of Hybrid Lipid-Polymer Nanoparticles
Hybrid lipid-polymer nanoparticles have demonstrated potential as drug delivery vehicles. The current proposal aims to use small angle neutron scattering (SANS) in combination... -
Understanding the structure of sunscreen formulations: where does the active ...
The negative effects of exposure to ultraviolet rays, 290-400 nm, are well known. Long exposures to these rays often cause skin damage (e.g. skin burns, melanoma). Topical... -
Structure of Cellulose Nanofibril Gels with Different Surfactants
This proposal is part of a project based on understanding the formation of gels in suspensions of partially oxidised cellulose nanofibrils and small amounts of additives, such... -
Structural Observation of the Self-Assembly Kinetics of Cyclic Peptide Nanotubes
Cyclic peptides with alternating side chain stereochemistry are capable of self-assembling into long nanotubes. The conjugation of polymers to these peptides renders the... -
Mixed surfactants for positive synergism in dense CO2
This proposal aims to explore a cheaper and more environmental-benign surfactant system for yielding efficient water/CO2 microemulsions. The new surfactants permit high... -
Self-assembly of methyl ester sulfonate(MES) and sulfobetaine surfactant mixt...
The MES is representative of a promising group of anionic surfactants which have the potential for improved performance and biocompatibility / biosustainability, and their... -
Self-assembly of lipid and triblock copolymer-based amphiphiles for drug deli...
Soft self-assembled structures have been extensively used as drug nanocarriers. Their building blocks, naturally occurring and synthetic amphiphiles (lipids or block... -
Interaction of polypeptides with surfactants: SANS study of solution aggregation
This proposal constitutes part of our ongoing study towards understanding the solution aggregation of collagen based polypeptides and their interactions with model surfactants.... -
Exchange kinetics of telechelic Cn-PEO-Cn micelles: effect of conformation an...
The microscopic dynamics of associative polymers that self-assemble into micellar structures play a key role for their macroscopical properties, with important implications for... -
Competitive interactions in polymer-particle-surfactant blends
Many formulations comprise distinct chemical species that exhibit antagonistic or synergistic interactions that result in unpredictable behaviour. Previous work from our group... -
Molecular Mechanistic Processes of Complexation between DNA and Cationic Copo...
It is difficult for the naked external gene to become internalized due to its similar charge to the extracellular membrane surface. Various cationic copolymers and cationic... -
Aggregation behaviour in solution of cationic conjugated polymers and oligomers
In the proposed experiments we extend previous work on characterization of aggregates formed by cationic conjugated polymers and oligomers in water. Particular emphasis will be... -
How do polymeric de-emulsifiers work? Contrast variation studies with model w...
The project is to understand fundamental structure-performance relationships of chemical demulsifiers in water-in-crude oil (w/o) systems. In particular, to understand how... -
Perfluorocarbon-loaded polymeric nanoparticles with multiple perfluorocarbon ...
Ultrasound is a very attractive and patient-friendly imaging technique, as it is easy to use, fast and non-invasive. Nevertheless, its use is severely limited by the low... -
Solution aggregation of short peptide surfactants
Short peptide sequences consisting of hydrophobic and hydrophilic amino acid units are capable of self-assembly to lead to interfacial adsorption and solution nano-aggregation.... -
Structure determination of solution aggregation of single alkyl chain PC surf...
We have synthesised alkyl phosphorylcholine (CnPC) surfactants in hydrogenated and deuterated form and have determined their solution aggregation using SANS. In this part of... -
Polymer displacement by surfactant at colloidal interface
The interactions of neutral polymers with surfactants have a key role in detergency and are systems of current academic and commercial interest. Here, we propose to study the... -
Interaction of Lignosulphonates with model surfactant systems by Small Angle ...
With the biobased economy growing substantially and pressure to reduce reliance on palm and crude oil derived materials, it is vital that the Home and Personal Care industry... -
Fundamentals of molecular self-assembly in deep eutectic solvents (DES)
Deep eutectic solvents (DES) are considered promising green solvents for future industrial formulations due to their biocompatibility, low cost, green production, and... -
Molecular Collapse and Conformation of Low Molecular Mass Polyacrylic Acid an...
There is conflicting information about properties of polycrylic acid and its behaviour in aqueous solution. This proposal for an investigation by SANS that is directed at...