114 datasets found

Lung surfactant protein B, SP-B, interacts with lipids at the air-water interface of the lung where its presence is vital for correct respiratory function. SP-B and its...

We recently completed an experiment on LARMOR at ISIS that proved that each individual neutron prepared for a Spin Echo Small Angle Neutron Scattering (SESANS) measurement is in...

Exosomes are released by cells are responsible for cell-cell communication of macromolecules and the development of disease such as cancer. These nanoparticles are loaded with...

For polymer vesicles to act as effective molecular delivery systems we must efficiently encapsulate a molecular payload within the vesicle. We would like to use neutron...

The proposed project is aimed at determining the nucleation/growth processes and structures (metal distributions and solvent population/distribution) of metallic films deposited...

Beta-arrestins are proteins that regulate GPCR signaling, e.g. by recruiting endocytic components to remove the receptor from the plasma membrane. Our fluorescence microscopy...

Neutron reflectometry will be used to probe the scattering length density profile in tethered films of block copolymers grafted onto silicon substrates. The tethered...

Here we propose a study that will contribute to the final challenges of PhD training programme (Emma Palin). We will study the electrochemical dissolution of a bi-metallic films...

The immersion deposition of silver onto copper and brass from deep eutectic solvents (DES) is a novel method for protecting the surface of printed circuit boards. Background...

We propose a detailed study of the interfacial structuring of a non-halogenated, and tribologically relevant, ionic liquid (IL) at an electrified interface, as a function of...

The spin Seebeck effect is a newly discovered phenomenon that if harnessed, could result in a significant improvement of the efficiency of thermoelectric energy generators. Spin...

The formation of a protein corona occurs on all surfaces exposed to biological systems and understanding of how this corona forms is vital for many aspects of medicine and for...

In bacteria, mechanosensitive ion channels such as MscL protect cells against osmotic shock, but, as with all ion channels, they have the potential to act as an Achilles heel,...

Exposure to ozone gas can cause inflammation of the airways and breathing difficulties. The initial reaction of ozone is thought to be predominantly with lipids present in the...

'Floating LSupported Bilayers' (FSB's) have become the 'standard' systems used for studying membrane systems using reflectivity at ISIS and other facilities. They are reliable,...

Hydrogels are widely used in biomaterials science, much due to excellent protein resistance, and physicochemical properties similar to biological tissue. Charge neutrality is...

PPO-PEO-PPO copolymer-based lubricant with extreme pressure or friction modifier additives has been introduced as boundary lubricant in metal forming. The Pluronic reverse...

PVA film is widely used as a non-toxic water soluble polymer. This proposal relates to its use in unit dose detergent pouches where plasticised PVA film stores a concentrated...

Meibomian lipids spread on the surface of tears to enable formation of a stable film. Our data show that meibum forms duplex films that have physical properties not emulated by...

The key to the use of polymer vesicles as effective molecular delivery systems is in the ability to efficiently encapsulate a molecular payload within the vesicle. We would like...