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Organization of mitochondrial membranes upon oxidative stress: Impact on apop...
Mitochondria are not only the powerhouse of the cell, but are also involved in cellular suicide via apoptosis (programmed cell death). The mitochondrial apoptotic pathway is a... -
Characterisation of the PDOS in 3He NSF cell materials
This dataset has no description
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Probing membrane localisation of molecular rotors (NR)
A number of important biological processes, such as intracellular transport and signal transduction depend on the viscosity and the distribution of microdomains in cells. We... -
Acid /amine complexation on an iron oxide /Oil interface
This experiment seeks to characterise the monolayer composition and structure of binary mixtures of fatty acid and amine. This represents a key additive system used commercially... -
In situ study of destruction of a denatured surface protein by protease (Savi...
New detergents will increasingly rely on sustainable products and the use of enzymes will become ever more important. However, the process of destruction of stains (often... -
Effect of Temperature on the Transbilayer Structure of a Model Erythrocyre Me...
In recent years, it has become understood that rather than being homogenous mixtures, biomembranes show a complex phase behaviour, with regions of uniform phases, and others... -
Conformational analysis of subtilin / lipid II binary antibiotic/target membr...
We propose to use neutron reflection to characterise the position and shape of subtilin/lipid II pore complexes as well as to characterise the kinetics of subtilin-lipid II and... -
Neutron reflectometry from surface of liquid 3He/4He film on silicon wafer
As it was predicted theoretically by Andreev at zero temperature for dilute 3He in 4He mixtures, 3He atoms will form a 2D Fermi liquid at liquid helium surface. Direct... -
pH-control of swelling and charge neutralization of thin hydrogel films
Hydrogels are widely used in biomaterials science, much due to excellent protein resistance, and physicochemical properties similar to biological tissue. Charge neutrality is... -
Nature of the protein corona on nanoparticle surfaces
When nanoparticles enter a biosytem they rapidly acquire a protein corona. The nature of the outer part of this corona will determine the response of the biosystem to the... -
Effect of calcium ions and ionic strength on model bilayer structure
Calcium ions have been shown in a preliminary experiment to have a dramatic effect on the thickness and structure of free supported bilayer films. In this proposal we... -
Neutron reflectometry from surface of liquid 3He/4He film on silicon wafer
A superfluid helium film can host a variety of exotic quantum phenomena, such as the topological BerezinskiiKosterlitzThouless transition, Rollins film flow and Third sound.... -
The effect of fatty acids on the adsorption of HSA at the silica water interface
The primary biological function of albumins is to be fatty acid carriers. The complexation of fatty acids to the albumin is expected to have a strong effect on its adsorption... -
Quantum Entanglement of Neutron Spin, Path and Energy
What does a quantum particle do when you are not looking at it? For a classical moving object, like a golf ball, we know its trajectory even when we are not looking at it. This... -
The interaction of oxidatively damaged lung proteins with anionic lipids
Lung surfactant protein B, SP-B, interacts with lipids at the air-water interface of the lung where its presence is vital for correct respiratory function. SP-B and its... -
Development of neutrons as entangled quantum probes
We recently completed an experiment on LARMOR at ISIS that proved that each individual neutron prepared for a Spin Echo Small Angle Neutron Scattering (SESANS) measurement is in... -
Investigation of the translocation potential of therapeutic macromolecules in...
Exosomes are released by cells are responsible for cell-cell communication of macromolecules and the development of disease such as cancer. These nanoparticles are loaded with... -
The hydration and ordering of lamellar block copolymer films prior to the for...
For polymer vesicles to act as effective molecular delivery systems we must efficiently encapsulate a molecular payload within the vesicle. We would like to use neutron... -
Effect of galvanostatic electrochemical control function on metal alloy depos...
The proposed project is aimed at determining the nucleation/growth processes and structures (metal distributions and solvent population/distribution) of metallic films deposited... -
Membrane Composition-Dependent Interaction between Beta-Arrestins and Lipid M...
Beta-arrestins are proteins that regulate GPCR signaling, e.g. by recruiting endocytic components to remove the receptor from the plasma membrane. Our fluorescence microscopy...
