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Antimicrobial Peptide Binding & Rearrangement in Model Membranes ¿ Building a...
Antimicrobial peptides (AMPs) are attractive drug candidates because of their selectivity and speed of action against bacteria. We have developed a novel approach to delivering... -
Neutron Reflectivity Study of Antimicrobial Peptides Interacting with Lipopol...
The outer membrane (OM) of gram negative bacteria is mainly constituted of highly polydisperse and amphiphilic lipopolysaccharide (LPS), an endotoxin which is accompanied by... -
Probing the internal structure of gene delivery vehicles using contrast varia...
Gene delivery vehicles, known as LPD complexes, prepared from mixing cationic lipid vesicles (L) with cationic peptide (P) and DNA (D) have proven to be very effective at... -
Interaction of keratin with surfactants studied by SANS
This proposal constitutes part of our ongoing study towards understanding how keratin, an important protein component of hair and skin, interacts with ionic surfactants using... -
The influence of transmembrane potential on the orientation of antimicrobial ...
Natural antimicrobials are of great interest, since they are antibiotics that act on the biological membrane, and it is believed that this makes it far more difficult for... -
Dynamics of amyloid protein fibril growth using isotope-labelled SANS
This proposal aims use a novel approach whereby deuterated amyloid peptide fibrils are givenhydrogenated growing ends, and analysed using SANS. The data will enable us to... -
Surface adsorption of short peptide surfactants
Short peptide sequences consisting of hydrophobic and hydrophilic amino acid units are capable of self-assembly to lead to interfacial adsorption and solution nano-aggregation.... -
A QENS Study of the Effect of Antimicrobial Peptide on Lipid Chain Dynamics
This dataset has no description
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Neutron scattering investigation of the influence of high hydrostatic pressur...
Amyloid fibrils are highly organized filamentous structures formed by the self-assembly of polypeptides. This proposal is to study the effect of pressure on the structure of... -
Surface properties of biogenic polyamine-surfactant mixtures
Polyions and biogenic polyamine are ubiquitous in many important biochemical functions. We propose here to use neutron reflectivity to investigate their potential to induce and... -
Probing the kinetics of the formation of lipid, peptide and DNA/siRNA complex...
Complexes prepared from cationic, dichain lipid (L) vesicles, positively chargely targeting peptides (P) and negatively charged DNA (D) or siRNA (R), known as LPDs and LPRs... -
Conformational analysis of subtilin / lipid II binary antibiotic/target membr...
We propose to use neutron reflection to characterise the position and shape of subtilin/lipid II pore complexes as well as to characterise the kinetics of subtilin-lipid II and... -
Solution aggregation of short peptide amphiphiles
Short peptide sequences consisting of hydrophobic and hydrophilic amino acid units are capable of self-assembly to lead to interfacial adsorption and solution nano-aggregation.... -
Do cardiolipins play a role for the mode of action of antimicrobial peptides?...
Antimicrobial peptides (AMPs), also called host defense peptides, are part of the innate immune system of essentially all species, from bacteria themselves to mammals to protect... -
Amyloid β peptide and α-synuclein association at lipidmodel membranes
We plan to investigate the interaction between amyloid proteins and model biomembranes deposited on solid surfaces. The model membranes will be single zwitterionic and mixed... -
Characterisation and peptide resistance capabilities of bacterial membrane mi...
Lysylphosphatidylglycerol (LPG) is a major constituent of the plasma membrane of the bacterial pathogen methicilin resistant Staphylococcus aureus (MRSA), which has been... -
Further Studies on the Gating Mechanism of an Antimicrobial Peptide Using Con...
Antibiotic peptides are generally small, simple, usually alpha-helical peptides, which nevertheless show quite complex biological behaviour. We have been studying the gating... -
dDMSO+buffer-borate in N8
This dataset has no description
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XB1293014: BrAV-d-2AA_D2O_gel_TRANS
This dataset has no description
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Solution aggregation of short peptide surfactants
Short peptide sequences consisting of hydrophobic and hydrophilic amino acid units are capable of self-assembly to lead to interfacial adsorption and solution nano-aggregation....
