The exposure of Laternula elliptica to nanoparticles (nanoplastics and nano-metals), during summer conditions is expected to affects their physiology at molecular level. The main aim was assess early molecular effects of realistic concentrations of nanoparticle emerging pollutants on a key Antarctic benthic species: the filter-feeding mollusc Laternula elliptica. This evaluating the transcriptional responses of singled and combined exposures to nano-polystyrene and nano-Titanium Dioxide