Interactions between contaminants exposure and genetic polymorphisms in relation to health

The Nunavik Health Survey was conducted in fall 2004. 929 participants accepted to enter the cohort study (follow up). A food frequency questionnaire and a 24h-recall in 1000 participants have been used to calculate various macro and micro nutrients intake. Legacy and emerging POPs, CALUX (dioxin like activity), mercury Oxidative parameters (LDL-Ox), paraxonase-1 (PON1) activity and concentration Holter (HRV), carotid ultrasound (IMT), blood pressure and confounders BMI, sitting BMI and diabetes parameters (insulin and blood glucose) were assessed. Red blood cell (n=1000) and plasma (n=500) fatty acids available. All medical files have been scanned and interpreted. Statistical analyses were conducted for the influence of enotyped polymorphisms on the associations between exposure data (POPs and heavy metals) and CVD risk factors in adults. Obesity and POPs (legacy, dioxin-like and emerging) in adults: We assessed if candidate polymorphisms interact with dioxin-like PCBs and emerging POPs in relation to obesity (BMI, sitting BMI, impedance data). Blood pressure and Hg in adults: Interactions between candidate polymorphisms and mercury in relation to systolic, diastolic and pulse pressure. Heart variability and pulse and Hg in adults: Key polymorphisms have been investigated for their interaction with mercury exposure in relation to HRV indices that are derived from a 2-hour Holter monitoring in adults. Oxidation in adults and Hg or POPs: The level of plasmatic LDL oxidation has been measured during the Qanuippitaa survey, as a potential marker of oxidative stress. Oxidized LDL has been tested for their association with contaminants and polymorphisms of interest has been investigated for their modifying effects. Diabetes in adults and POPs in adults: We investigated the relationship between PCBs and diabetes markers (insulin, fasting glucose, HOMA indice) and verified if some polymorphisms may influence this relation. Lipid metabolism in adults and POPs (legacy, dioxin-like and emerging exposure): Interaction between polymorphisms involved contaminant metabolism or in lipid metabolism has been analyzed for their interaction with POPs exposure in relation to serum lipid profiles (HDL and LDL cholesterol, triglycerides). Carotid thickness (IMT) and Hg in adults: Polymorphisms mostly included in drug-metabolizing genes have been assessed for their modifying effects of the association between mercury exposure and IMT.

Identifier
Source https://www.polardata.ca/pdcsearch/PDCSearchDOI.jsp?doi_id=11042
Metadata Access http://www.polardata.ca/oai/provider?verb=GetRecord&metadataPrefix=fgdc&identifier=11042_fgdc
Provenance
Creator Dewailly, Éric; Ayotte, Pierre; Muckle, Gina
Publisher Canadian Cryospheric Information Network
Contributor Polar Data Catalogue
Publication Year 2015
Rights Research programs, CCIN, or ArcticNet take no liability for the use or transmission of this data
OpenAccess true
Contact suzanne.cote(at)crchul.ulaval.ca; pdc(at)uwaterloo.ca
Representation
Language English
Format Computer file
Discipline Environmental Research
Spatial Coverage (-64.000W, 55.000S, -64.000E, 55.000N)
Temporal Coverage Begin 2004-09-01T00:00:00Z
Temporal Coverage End 2009-12-31T00:00:00Z