Genetic polymorphisms to improve interpretation of contaminant exposure and risk in Inuit (Nunavik)

The long-term objective of our research program is to better understand how Inuit processes contaminants so that dietary exposure assessments and linkages to adverse health outcomes can be improved. The ultimate goal is to arm public health decision makers with knowledge to help identify the most susceptible subpopulations and make informed and objective risk assessments. The short-term goal is to test the hypothesis that analysis of genetic polymorphisms (focus on environmentally-responsive genes within key biological pathways) will increase understanding and utility of exposure biomarkers of mercury, PCBs, and other persistent organic pollutants. In other words, inter-individual variation in key toxicokinetic genes will influence dietary exposure (survey)-biomarker (blood contaminants) relationships. The specific aim is to measure single nucleotide polymorphisms (focus on toxicokinetic pathways such as glutathione, selenoproteins, metallothioneins, amino acid transporters) in blood samples obtained from inhabitants of Nunavik (n=669 participants) as part of the 2004 Qanuippitaa Survey, and to relate this genetic data to already collected and robust information on dietary exposures to contaminants (via surveys) and resulting biomarkers (via chemical analyses in blood of mercury, cadmium, lead, PCBs, PBDEs, toxaphene, DDE/DDT, chlordane).

Identifier
Source https://www.polardata.ca/pdcsearch/PDCSearchDOI.jsp?doi_id=12660
Metadata Access http://www.polardata.ca/oai/provider?verb=GetRecord&metadataPrefix=fgdc&identifier=12660_fgdc
Provenance
Creator Basu, Niladri; Ayotte, Pierre; Chan, Laurie; Hegele, Robert; Lemire, Melanie
Publisher Canadian Cryospheric Information Network
Contributor Polar Data Catalogue
Publication Year 2017
Rights Research programs, CCIN, or ArcticNet take no liability for the use or transmission of this data
OpenAccess true
Contact niladri.basu(at)mcgill.ca; pdc(at)uwaterloo.ca
Representation
Language English
Format Computer file
Discipline Environmental Research
Spatial Coverage (-79.000W, 55.000S, -64.000E, 62.000N)
Temporal Coverage Begin 2016-01-01T00:00:00Z
Temporal Coverage End 2016-04-01T00:00:00Z