Measurements of the two horizontal components of the currents were collected with the Ship-mounted Acoustic Doppler Current Profilers (S-ADCP) in the Gulf of Guinea during cruises carried out from 2007 to 2016 in the framework of the programs «Prediction and Research morred Array in the Tropical Atlantic» (PIRATA ; Bourlès et al., 2008) and « Etude de la circulation océanique et des échanges océan-atmosphère dans le Golfe de Guinée » (EGEE ; Bourlès et al., 2007), the French oceanographic component of the «African Monsoon Multidisciplinary Analysis» program (AMMA ; Redelsperger et al., 2006). The data have been processed with the CASCADE (Chaîne Automatisée de Suivi des Courantomètres Acoustiques Doppler Embarqués) software (Kermabon and Gaillard, 2011). This dataset is also be used in the framework of the EU PREFACE program (see http://preface.b.uib.no/).