Medicinal plants are a potential source of new drugs like antimicrobials. The need for new antimicrobials is necessitated by the fact that multi-drug resistance by bacteria is now a common phenomena. The medicinal plants used to treat infectious diseases in Delta were investigated as potential replacement for antibiotics used locally for the treatment of Staph infections. The ethnobotanical use of the plants used is shown in tables 1a and b. This was got from different literature and also by interviewing locals. Polar compounds were extracted with ethanol and methanol while non polar compounds were got with chloroform and n-hexane and are shown in figures 1, 2, 3, 4.These compounds and also aqueous extracts were got from the fifteen medicinal plants used were tested on the growth of the test organism Escherichia coli. the susceptibility of the test organism to the various extracts was accessed using the criteria set by ACCLS, 2012. The data indicates that while the test organism was not susceptible to any of the antibiotics tested but instead showed intermediate susceptibility. The data show that the test organism was susceptible to some of the plants tested and as such could be investigated further as potential sources of new drugs for the treatment of staph infections.