Toxicologic and immunologic effects of perinatal exposure to the brominated diphenyl ether (BDE) mixture DE-71 in the Sprague-Dawley rat

Brominated diphenyl ethers (BDEs) are persistent environmental contaminants found in human blood, tissues and milk. To assess the impact of the commercial BDE mixture DE-71 on the developing immune system in relation to hepatic and thyroid changes, adult (F0) rats were exposed to DE-71 by gavage at doses of 0, 0.5, 5 or 25 mg/kg body weight (bw)/day for 21 weeks. F0 rats were bred and exposure continued through gestation, lactation and post-weaning. F1 pups were weaned and exposed to DE-71 by gavage from postnatal day (PND) 22 to 42. On PND 42, half of the F1 rats were assessed for toxicologic changes. The remaining F1 rats were challenged with the T-dependent antigen keyhole limpet hemocyanin (KLH) and immune function was assessed on PND 56. Dose-dependent increases in total BDE concentrations were detected in the liver and adipose of all F0 and F1 rats. In F0 rats, increased liver weight, hepatocellular hypertrophy and decreased serum thyroxine (T4) were characteristic of DE-71 exposure. In F1 rats perinatal DE-71 exposure caused a non-dose-dependent increase in body weight and dose-dependent increases in liver weight and hepatocellular hypertrophy. Serum T3 and T4 levels were decreased. In spleen from DE-71 exposed rats the area occupied by B cells declined while the area occupied by T cells increased; however, cellular and humoral immune responses to KLH challenge were not altered. Thus hepatic and thyroid changes in rats exposed perinatally to DE-71 were associated with altered splenic lymphocyte populations, an effect which has been linked to hypothyroidism.

Identifier
Source https://www.polardata.ca/pdcsearch/PDCSearchDOI.jsp?doi_id=11097
Metadata Access http://www.polardata.ca/oai/provider?verb=GetRecord&metadataPrefix=fgdc&identifier=11097_fgdc
Provenance
Creator Dr. Genevieve Bondy, Health Canada; Dr. David Lefebvre, Health Canada; Dr. Gerard Cooke, Health Canada; Dr. Michael Barker, Health Canada; Dr. Rekha Mehta, Health Canada; Dr. Syed Aziz, Health Canada; Mr. Paul Rowsell, Health Canada
Publisher Canadian Cryospheric Information Network
Contributor Polar Data Catalogue
Publication Year 2014
Rights Research programs, CCIN, or ArcticNet take no liability for the use or transmission of this data
OpenAccess true
Contact genevieve_bondy(at)hc-sc.gc.ca; pdc(at)uwaterloo.ca
Representation
Language English
Format Computer file
Discipline Environmental Research
Spatial Coverage (-141.000W, 60.000S, -60.000E, 90.000N)
Temporal Coverage Begin 2004-01-01T00:00:00Z
Temporal Coverage End 2005-12-31T00:00:00Z