Database for "The impact of amino acids on postprandial glucose and insulin kinetics in humans: a quantitative overview"

DOI

Different amino acids (AAs) may exert distinct effects on postprandial glucose and insulin concentrations. A quantitative comparison of the effects of AAs on glucose and insulin kinetics in humans is currently lacking. PubMed was queried to identify intervention studies reporting glucose and insulin concentrations after acute ingestion and/or intravenous infusion of AAs in healthy adults and those living with obesity and/or type 2 diabetes (T2DM). The systematic literature search identified 55 studies that examined the effects of L-leucine, L-isoleucine, L-alanine, L-glutamine, L-arginine, L-lysine, glycine, L-proline, L-phenylalanine, L-glutamate, branched-chain AAs (i.e., L-leucine, L-isoleucine, and L-valine), and multiple individual L-AAs on glucose and insulin concentrations. Oral ingestion of most individual AAs induced an insulin response but did not alter glucose concentrations in healthy participants. Specific AAs (i.e., leucine and isoleucine) co-ingested with glucose exerted a synergistic effect on the postprandial insulin response and attenuated the glucose response compared to glucose intake alone in healthy participants. Oral AA ingestion as well as intravenous AA infusion was able to stimulate an insulin response and decrease glucose concentrations in T2DM and obese individuals. The extracted information is publicly available and can serve multiple purposes such as computational modeling.

Study details and time-series data are located in Dataset_Systematic_Review.xlsx

Identifier
DOI https://doi.org/10.34894/RNZI0A
Related Identifier https://doi.org/10.3390/nu12103211
Metadata Access https://dataverse.nl/oai?verb=GetRecord&metadataPrefix=oai_datacite&identifier=doi:10.34894/RNZI0A
Provenance
Creator van Sloun, Bart ORCID logo; Goossens, Gijs H.; Erdos, Balazs; Lenz, Michael; van Riel, Natal; Arts, Ilja C.W.
Publisher DataverseNL
Contributor Wauters, Fieke
Publication Year 2020
Rights CC0 Waiver; info:eu-repo/semantics/openAccess; https://creativecommons.org/publicdomain/zero/1.0/
OpenAccess true
Contact Wauters, Fieke (Maastricht University)
Representation
Resource Type Dataset
Format application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
Size 122045
Version 1.1
Discipline Construction Engineering and Architecture; Engineering; Engineering Sciences; Life Sciences; Medicine