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Structure of lipid monolayers following oxidative damage
Lipids form the major component of cell membranes, which separate the contents of the cell from the external environment. The oxidation of lipids within biological membranes is... -
Polymer-surfactant films containing glucose sensors
This proposal continues our research on mesostructured surfactant templated polymer films that form spontaneously at the air-water interface. Our recent research has shown it is... -
Structural investigations of low-temperature "trapped solutions" of C60 fulle...
We propose a series of neutron scattering measurement to determine the water structure in amorphous H2O/C60 fullerene vapour deposits. We believe that these samples, prepared by... -
Structure of antibiotic mixtures in lung surfactant membrane models at the ai...
Clarithromycin and Levofloxacin are essential antibiotics used to treat bacterial infections such as tuberculosis and pneumonia. Lung surfactants may be used as drug carrier of... -
Templating of titania films in cationic-anionic surfactant polymer solutions
In this proposal we wish to continue our recent work using polyelectrolyte-surfactant films as templates for inorganic structures, in this case titania.... -
Deposition of lipid bilayer through peptide-discs
We are developing a new protocol for the preparation of lipid bilayers suitable to host membrane proteins with control on their orientation. Our proposed strategy is based on... -
calcite water interface
The interface of CaCO3 (calcite) and water is of paramount importance in a number of key academic and industrial areas, including scale deposition in domestic and industrial... -
Competitive adsorption in hydrophobin-surfactant mixtures
Hydrophobins are small compact secreted fungal proteins which are strongly surface active and adhere to both hydrophobic and hydrophilic surfaces. Their strong surface activity... -
Nanophase separation in monolayers of stratum corneum mixtures
There is considerable effort being put into the modelling of the outer layer of skin, the stratum corneum, because of impending EU restrictions on the use of animal skin for... -
manipulating surface adsorption usinf ethoxylated polyelectrolytes
The strong interaction between polyelectrolytes and ionic surfactants can result in pronounced surface adsorption and the formation of surface multilayer structures. This... -
Magnetic contrast NR to resolve MscL opening under PXG challenge: influence o...
In bacteria, mechanosensitive ion channels such as MscL protect cells against osmotic shock, but, as with all ion channels, they have the potential to act as an Achilles heel,... -
Structural modelling of meibomian lipid films
Meibomian lipids spread on the surface of tears to enable formation of a stable film. Our data show that meibum forms duplex films that have physical properties not emulated by... -
Surface adsorption in highly non-ideal multi-component surfactant mixtures
This proposal is about the development of sustainable detergency based formulations, based on the blending of biosurfactants with conventional surfactants, and is part of a CASE... -
Structure-function studies of Replication Protein A, a crucial player in geno...
Replication protein A (RPA), the eukaryotic ssDNA binding protein, is a heterotrimeric protein required for almost all aspects of cellular DNA metabolism. RPA binds... -
Understanding the interfacial behaviour of bile salts to better engineer lipi...
The current project aims at elucidating how bile salts (BS) structure influences their interfacial behaviour and their impact on fat digestion. Neutron reflectivity (NR) is the... -
The role of tryptophan in puroindoline/purothionin cooperative binding to bio...
The puroindoline (PIN) and purothionin (PTH) families of polypeptides both occur in wheat and are implicated in antipathogenic defence mechanisms, and of interest for potential... -
impact of mutlivalent counterions on surfactant adsorption
We request NR beam time on SURF to study the impact of multivalent counterions on the surface adsorption of alkyloxyethylene sulfate surfactants and alkyloxyethylene sulphate /...