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Effect of formulation method and lipid composition on liposome lamellarity
Liposomes are vesicles comprising a phospholipid membrane bilayer around an aqueous core. They are well-established in the fields of drug delivery and diagnostics. To translate... -
Small-angle neutron scattering study of human growth hormone-surfactant compl...
Liquid pharmaceutical formulations are commonly comprised of proteins and surfactants, which interact in solution in order to provide an increase in system stability. Although... -
Solution aggregation of short peptide surfactants
Short peptide sequences consisting of hydrophobic and hydrophilic amino acid units are capable of self-assembly to lead to interfacial adsorption and solution nano-aggregation.... -
The structure of the Bam complex, the Gram-negative outer membrane protein fo...
The proteins of the outer membrane of Gram-negative bacteria are critical for bacterial survival, from providing basic physiological functions, to impairing virulence and... -
Effect of drug on the micelles formed by ionic surfactants
The aim of the study is to use SANS in combination with contrast variation to determine the effect of solubilising the lipophilic drug, testosterone propionate, in micelles... -
DOMAIN MOVEMENT IN CYTOCHROME P450 REDUCTASE
Cytochromes P450 play a key role in drug metabolism in man. Electrons are supplied to the cytochromes by NADPH through the flavoprotein NADPH-cytochrome P450 reductase (CPR).... -
Polymer-Lipid Nanodisc Self-assembly Processes Using Stop Flow
Polymer stabilized lipid nanodiscs offer enormous potential as tools for enabling membrane protein structural studies & biophysics. Polymer stabilized lipid bilayer discs... -
Molecular Mechanistic Processes of Complexation between DNA and Cationic Copo...
We have previously used LOQ to identify the complex (polyplex) structures formed between a short single strand DNA and a cationic diblock copolymer MPC30-DEA60. The SANS... -
Structure of the interaction between complement factor H (CFH) and complement...
Complement comprises key proteins in innate immunity that forms a major defence and clearance system in blood. CFH is the major regulator of active C3b formed from C3. C3d is a... -
Kinetic Study of the Mechanistic Complexation Process Between DNA and Cationi...
We propose to use the new SANS2d to study the dynamic structural evolution in the couse of the formation of DNA-cationic polymer complexes. The dynamic process and the mixing... -
Solution Structure of the OmpF-TolA complex
Gram negative bacteria cause a wide range of diseases including meningitis, bubonic plague, gonorrhoea, diarrhoea, Legionnaires' disease and cholera. Their outer membrane... -
Determining the structure of the colicin OmpF complex
Large multiprotein complexes are the new frontier in structural biology. Individual proteins may be solved by X-ray crystallography but the relationships between subunits and... -
OB Buffer - 40% D2O_SANS
This dataset has no description
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Lipid exchange dynamics between native lipoprotein particles and human cell m...
Atherosclerosis is the primary cause of death in westernized societies. Clinical indicators include not only the net lipoprotein concentration but also the ratio between the... -
Using SANS2D to resolve the opening of MscL clusters in proteoliposomes in re...
In bacteria, mechanosensitive ion channels such as MscL protect cells against osmotic shock. Although crucial for protecting cells, as with all ion channels, they have the... -
Solubilisation of Drug Molecules in Nonionic Surfactant Micelles: Structural ...
This proposal aims to understand how the structure of non-ionic surfactant micelles affects the amount of fungicides solubilised. SANS is a technique unique for unravelling the... -
Elucidating the unique role of non-standard collagen helices in forming key p...
The collagens are the most abundant proteins in mammalian systems, comprising up to 25% of human proteins. Their three-stranded triple helix structures are a major determinant... -
DNA unwinding mechanism of the archaeal helicase PabMCM
The process of cell division requires precise duplication of the genetic material. The separation of the two strands of DNA and the progression of the replisome are driven by... -
Influence of polymer molecular weight on polymer stabilized lipid nanodiscs
Nanostructured lipid aggregates offer enormous potential as tools for membrane structural biology and biophysics. Poly(Styrene-Maleic Acid) stabilized lipid nanodiscs have a... -
Micelle formation from model surfactant binary and ternary compositions in th...
The effects of electrolytes on SLES3, C12E8 and LAS4 has been extensively studied, especially the effect on the critical micelle concentration of each surfactant. We wish to...