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Understanding the true biological function of Plant Non Specific Lipid Transf...
Non specific lipid transfer proteins are a family of basic, cysteine rich proteins found in a wide range of plant species. The biotechnological role of these proteins in beer... -
The interaction of oxidatively damaged lung proteins with anionic lipids
Lung surfactant protein B, SP-B, interacts with lipids at the air-water interface of the lung where its presence is vital for correct respiratory function. SP-B and its... -
Solution Structure of the OmpF-TolA complex
Gram negative bacteria cause a wide range of diseases including meningitis, bubonic plague, gonorrhoea, diarrhoea, Legionnaires' disease and cholera. Their outer membrane... -
Determining the structure of the colicin OmpF complex
Large multiprotein complexes are the new frontier in structural biology. Individual proteins may be solved by X-ray crystallography but the relationships between subunits and... -
Dynamic Adsorption of the Fusion Protein HSA-NEP at the Silica-Water Interface
HSA-NEP is a fusion protein with potential uses in treating Alzheimers disease. It consists of Neprilysin, a peptide degrading enzyme, linked to HSA, the most common protein in... -
Neutron reflectivity studies of the interaction between a novel antimicrobial...
A Unilever proprietary technology has been shown to inhibit biofilm growth and development, and is also found to possess antimicrobial activity, effective both as a... -
Validating calorimetric self aggregation models: Self aggregation of cationic...
Ligand self aggregation is a common problem when studying interactions with bio(macro)molecules. In particular for techniques requiring relatively high ligand concentrations,... -
Investigation of the interactions of perfluoroalkyl substances with model wor...
Perfluoroalkyl substances (PFASs) are fully fluorinated, stabile, and surface-active compounds. They contain both a hydrophobic fluorinated carbon chain and an ionizable... -
The hydrophobic interaction A peptides and a lipid monolayer at the o...
This proposal relates to the study on the fundamental level, the hydrophobic interaction A peptides and a lipid monolayer at the oil-water interface. NR will be used to... -
Structural Study of Functional Nucleosome in Solution
Recently, it is reported that the functional nucleosomes, CENP-A nucleosome, H2A.Bbd nucleosome and hexasome, which include variant histone cores, could have flexible and mobile... -
Dynamics of amyloid protein fibril growth using isotope-labelled SANS
This proposal aims use a novel approach whereby deuterated amyloid peptide fibrils are givenhydrogenated growing ends, and analysed using SANS. The data will enable us to... -
Conformational analysis of subtilin / lipid II binary antibiotic/target membr...
Antibiotic resistance is pathogenic bacteria is a major clinical problem. Resistance to all antibiotiotic classes, currentl yin clinical use, has been reported. By contrast, the... -
Developing a general approach to resolution of accessory proteins bound to cl...
Endocytosis plays a central role in allowing the selective transport of molecules, via membrane-derived vesicles, into cells. Vesicle formation is controlled by a complex... -
Surface Layer Structures of Short Peptide Amphiphiles
Short peptide sequences consisting of hydrophobic and hydrophilic amino acid units are capable of self-assembly, leading to interfacial adsorption and solution nano-aggregation.... -
Radiation induced changes in block copolymer micelles
Block copolymer micelles have been used to encapsulate various chemotherapeutic drugs, which can be delivered to the tumour site using the so-called Enhanced Permeation and... -
Surface activity of biosurfactant (sophorolipid) / surfactant mixtures
Understanding the fundamental aspects of the surface adsorption and self-assembly of biosurfactant and biosurfactant / conventional surfactant mixtures is a major challenge for... -
Protein nanosheets assembled structures at the air-water interfaces for cell ...
Cell adhesion and proliferation at the surface of liquids such as oil droplets is a surprising phenomenon as it is typically accepted in the field of bioengineering that cells... -
The Structure of Ca- and Yb-ammonia Solutions: Polarons, Bipolarons and Elect...
In this experiment we propose to perform diffraction on isotopically substituted samples of Ca/Yb:ND/H3 and Ca/Yb:15ND3 at two concentrations (8 and 2 MPM) using the new NIMROD... -
Exploring the interactions between vesicles/viruses and supported lipid bilay...
Many biological processes occur at the interface of cells, at the so called cell membrane, such as internalization of biological nanoparticles, including virions, exosomes and... -
Laser-induced electron transfer in Trp-Tyr
We have recently performed a measurement of the dipeptide Tryptophanil-Tyrosine (Trp-Tyr) dissolved in deoxygenated water, illuminated by the 4th harmonic of the Nd-YAG laser...