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Structural modelling of meibomian lipid films
Meibomian lipids spread on the surface of tears to enable formation of a stable film. Our data show that meibum forms duplex films that have physical properties not emulated by... -
Structural characterisation of vaccine-adjuvant interactions using neutron re...
This dataset has no description
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Mimicking Pathogens : Floating Gram Negative Bacterial Membranes Containing t...
Recently we have been able to show two advances in the creation of realistic models of the Gram negative bacterial outer surface for use in biophysical and structural studies.... -
Antimicrobial Peptide Binding & Rearrangement in Model Membranes ¿ Building a...
Antimicrobial peptides (AMPs) are attractive drug candidates because of their selectivity and speed of action against bacteria. We have developed a novel approach to delivering... -
Magnetic contrast reflectometry to resolve transmembrane potential effects on...
The division of bacteria is controlled by the binding of proteins to the inner of the two lipid bilayer membranes that separates the inside of the cell from the outside world.... -
Head Group charging and anaesthetic Interaction with Model Bilayers
The mechanism of general anaesthetic action is poorly understood despite their widespread use. It is hoped that investigating the interaction of anaesthetics with lipid bilayers... -
A complex model of the bacterial outer membrane containing oriented proteins ...
The Outer Membrane (OM) is found in bacteria which cause plague, cholera & Legionnaire?s disease. It is important as; a barrier to antibiotics & the site of... -
The Kinetics of Ethanol Adsorption into Cholesterol Rich Bilayers
In a recent experiment carried out on SURF we have shown that on addition of ethanol to a DPPC model membrane, the anaesthetic initially diffuses to the bilayer surface followed... -
A model of the bacterial outer membrane containing both Outer Membrane Protei...
We have recently improved the stability and coverage of free standing bilayers (FSB) by the use of a supporting thiolipid layer on gold. The system has been investigated on... -
Surface modification in heteropolymer blends.
In recent years we have had considerable success with the surface modification of amorphous and crystalline thermal plastic polymers using multi-end functional additives. In... -
Effect of Nucleating Agents on Phase Behavior in thin film bulk heterojunctio...
Neutron reflection will be used to investigate the normal composition profile in thin films of blends of electron-donor poly(alkyl thiophene) and the electron-acceptor... -
Self-assembled Floating Lipid Bilayers: What Forces Are Causing the Bilayer t...
Recently (RB19100102) we have discovered that floating bilayers composed of fluid phase lipids can be produced by deposited vesicles onto charge modified oligo(ethylene... -
Neutron reflectivity studies of the interaction of amphotericin with model ce...
The increasing incidence of pathogenic fungi resistant to treatment with amphotericin (AmB) has created a demand for novel anti-fungal agents that can circumvent the pathogens¿... -
Magnetic contrast reflectometry to resolve transmembrane potential effects on...
The division of bacteria is controlled by the binding of proteins to the inner of the two lipid bilayer membranes that separates the inside of the cell from the outside world.... -
Adsorption of Sodium Bis-(2-ethylhexyl)phosphate on a-Alumina
In this proposal we investigate the adsorption of a key additive and functional group used in lubrication and wear applications using neutron reflection on a metal oxide... -
Using Magnetic Contrasts to Establish the Mechanism and Kinetics of Lipid Fli...
In order to maintain their asymmetric lipid distribution, cellular membranes have a number of means to translocate lipid molecules across the bilayer. On top of the well-studied... -
A study of hole injection efficiency for a model conjugated bilayer system
Polymer-based electronics have attracted huge interest due to their wide applicability to light emitting diodes, field effect transistors and photovoltaics. The aim of our... -
Probing membrane localisation of molecular rotors
A number of important biological processes, such as intracellular transport and signal transduction depend on the viscosity and the distribution of microdomains in cells. We... -
Formation of asymmetric free-standing bilayers with lipopolysaccharide in the...
We have recently improved the stability and coverage of free standing bilayers by the use of a supporting thiolipid layer on gold. The system has been investigated on POLREF and... -
Detailed Structure of Phospholipid Bilayers from Multiple Contrast Neutron Re...
In recent monolayer measurements, we have developed models for obtaining detailed structural information of phospholipid structures. The models employ a 'quasimolecular'...