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Formulating polymer solutions to stabilise polymeric foams
Polyurethane foams (PUFs) are commonly prepared by mixing Pluronic type copolymers and isocyanate reactive monomers in the presence of additives e.g. catalysts, blowing agent... -
Examination of Free Floating Models of the Gram-Negative Bacterial Outer Memb...
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CaCO3_H2O
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Self-assembly of lipid and triblock copolymer-based amphiphiles for drug deli...
Soft self-assembled structures have been extensively used as drug nanocarriers. Their building blocks, naturally occurring and synthetic amphiphiles (lipids or block... -
Resolving the manifold setting structure of protiated vs D2O portland cements
Models of cement have been formulated to further understanding. The dominant being Jennings layered colloid model. Therein, idealised silicate layers are interspersed with... -
Interaction of sugars and a model peptide
We propose to perform a NDIS experiments at the SANDALS diffractometer at T = 300 K on 7 aqueous solutions of NMA and trehalose and NMA and glucose, aimed at investigating the... -
Binding Particles with Proteins at Interfaces
Understanding and controlling the interaction of nanoparticles with biomaterials is key to alleviation of concerns about nanotoxicity. This knowledge can also be used to design... -
Temperature Effects and Kinetics of Thiolipid Adsorption to Gold Surfaces
We have a programme investigating the structure and function of protein scaffolds oriented on gold surfaces using sulfur chemistry for attachment. The aim is to direct the... -
The structure of the Bam complex, the Gram-negative outer membrane protein fo...
The proteins of the outer membrane of Gram-negative bacteria are critical for bacterial survival, from providing basic physiological functions, to impairing virulence and... -
Neutron diffraction of amorphous calcium carbonate
Amorphous calcium carbonate (ACC) is regularly listed as one of the known calcium carbonate phases, first being identified in 1984. Although ACC is inherently unstable, it is a... -
Hydrothermal synthesis and calcination of hydrotalcites
Hydrotalcites are anionic clays which have a variety of applications, including use as environmentally friendly catalysts and catalyst precursors. In this experiment we propose... -
Silica perturbation of the water structure around cationic micelles during te...
This proposal continues a new direction in our research on surfactant-templated inorganic materials. These nanostructured materials contain ordered arrays of surfactant micelles... -
Electrostatic Interactions between Floating Bilayers and Thiol Coated Interfa...
Bilayers which float below a self-assembled monolayer (SAM) coated solid support represent one of the most advanced membrane mimetics. Recently (RB 1720155) we assessed the... -
Ion Binding in Tetradecyltrimethylammonium Surfactant Micelle Solutions
This proposal continues our studies of surfactant micelles using NIMROD, to obtain previously inaccessible details of headgroup-ion interactions. In our previous experiments... -
Interplay of apoptosis regulating Bcl-2 proteins with mitochondrial membranes...
Mitochondria are not only the powerhouse of the cell, but are also involved in cellular suicide via apoptosis (programmed cell death). The mitochondrial apoptotic pathway is a... -
Structure of the myoglobin-trehalose-water system
In this proposal we will study the structure of the myoglobin-trehalose-water system. It is well known that trehalose has an excellent cryo- and bioprotective role for... -
Oxidation of gram-negative cell-wall proxy with OH radicals - kinetics and me...
Hydroxyl radicals may be used as disinfection agent in the advanced oxidation processes or tertiary treatment of waste and occasionally drinking water. We very recently oxidised... -
Tuneable Adsorption of Soft Colloids on Model Biomembrane
Understanding how nanoparticles interact with lipid bilayers will potentially have high impact on the development of new drug delivery systems, and on the investigation of their... -
Spontaneous surface multilayer formation in oligoamine ¿ surfactant mixtures
This proposal is part of a major EPSRC (EP/GR065705)/Unilever funded programme to develop and control the spontaneous formation of surfactant multilayer structures at... -
Swelling of Single Supported Bilayers ¿ First Systematic Investigation of the...
This proposal addresses bilayer swelling experiements on floating supported bilayers (FSBs) in the presence of biological buffers. Previous work on multilamellar vesicles has...