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Multilayering of Methyl Ester Sulphonates at the Air-Aqueous Interface
Surfactants usually form a single layer of molecules at the surface of water. We have shown, surprisingly, that under certain conditions more than one layer may form. When this... -
Self-assembly in biosurfactants and biosurfactant / surfactant mixtures
This proposal is part of a new project which is a collaboration between Oxford, Newcastle, Ulster, and Unilever on the development of sustainable laundry detergents, using... -
Polymer conjugates for drug delivery
Complex polymer architectures such as comb polymers have been studied for their highly customisable chemical properties. Potential applications have been identified in a wide... -
Interactions between Designed Antimicrobial Lipopeptides and Inner Membrane L...
Neutron reflection will be used to reveal the structural changes from different inner membrane leaflet models upon interacting with a group of antimicrobial lipopeptides with... -
Micelle formation from model surfactant binary and ternary compositions in th...
The effects of electrolytes on SLES3, C12E8 and LAS4 has been extensively studied, especially the effect on the critical micelle concentration of each surfactant. We wish to... -
Low temperature adsorption of model binary surfactant mixtures in the presenc...
We wish to extend previous studies on the adsorption of binary surfactant systems at the air water interface by the addition of NaCl and CaCl2: mimicking the 'hard water'... -
Unusual structural change in geminis above the critical micelle concentration
gemini surfactants are essentially two surfactants joined by a linking chain. We have extensively explored cationic geminis at the air/water interface and they exhibit a range... -
Antibiotic paths through the bacterial outer membrane: The strange case of va...
Gram-negative bacteria, which cause a variety of diseases including meningitis, plague, sepsis and food poisoning, are becoming increasingly antibiotic resistant. One reason is... -
Complex evolution of solution microstructure in LAS / nonionic surfactant mix...
This proposal is part of a broad programme of collaborative research between RAL / Oxford and Unilever, using predominantly scattering techniques to investigate the nature of... -
Organization of mitochondrial membranes upon oxidative stress: Impact on apop...
Mitochondria are not only the powerhouse of the cell, but are also involved in cellular suicide via apoptosis (programmed cell death). The mitochondrial apoptotic pathway is a... -
Multilayering of Isostearic Methyl Ester Sulphonate at the Air-Aqueous Interf...
Surfactants usually form a single layer of molecules at the surface of water. We have shown that under certain conditions more than one layer may form. in which case the system... -
Interaction of polypeptides with surfactants: aqueous solution aggregation
This proposal constitutes part of our ongoing study towards understanding how collagen based polypeptides interact with ionic surfactants using SANS. Both SDS and C12TAB will be... -
Structure of aggregation of peptide surfactants: effect of the size of amino ...
Peptide surfactants are a group of interesting biomimetic amphiphiles capable of forming a range of nanostructures. The aim of this work is to use SANS to determine the... -
Model anionic/non ionic surfactant adsoption at the interface below room temp...
An experiment performed on INTER last year found extreme non ideal mixing between C12E8/SLES3 at the air water interface: this feature became more extreme as the temperature... -
NR study of surface adsorption of antibodies with and without non-ionic surfa...
Nonionic surfactants usually do not show affinity to proteins and they work via competitive surface and interfacial processes in abinary mixture. However, we show in this work... -
Electrolyte induced self-assembly of methyl ester sulphonate surfactants
The addition of multivalent counterions (Al3+, Mg2+) induces multilayer adsorption of ionic surfactants at interfaces. It is associated with strong wetting conditions, invoking... -
Elucidating molecular mechanism of membrane disruption by designed α-hel...
We have previously shown that peptides such as G(IIKK)4I-NH2 (G4) can kill bacteria and inhibit cancer cell growth whilst remaining benign to mammalian host cells. We have also... -
Self-assembled Floating Lipid Bilayers: What Forces Are Causing the Bilayer t...
Recently (RB19100102) we have discovered that floating bilayers composed of fluid phase lipids can be produced by deposited vesicles onto charge modified oligo(ethylene... -
Structure of a cationic polyelectrolyte adsorbed at an oppositely charged sur...
Adsorption of a charged polyelectrolyte onto an oppositely charged substrate is important for the understanding of many natural molecular events as well as for the development... -
Co-adsorption of monoclonal antibodies and non-ionic surfactants at the air/l...
Nonionic surfactants usually do not show affinity to proteins and they work via competitive surface and interfacial processes in a binary mixture with protein. However, we show...