The Canadian Arctic is experiencing intense socio-cultural stresses as a result of climate change, resource extraction, and associated shifts in the environment. These changes present major challenges to health, with the most acute impacts experienced among Inuit populations reliant on the environment for sustenance and livelihoods. Globally, improved environmental health surveillance has been identified as a critical adaptation strategy to respond to environmental health impacts. There is a repeated call for the creation of health surveillance that uses novel approaches, integrates new types of data, and includes multiple knowledge sources. This is important for Indigenous communities, as they are inadequately served and engaged in environmental health monitoring, particularly in the North. Responding to this gap, this program will work in collaboration with Inuit communities and knowledge users to develop and implement i) a community-based environment-health sentinel surveillance and response system in Rigolet, Nunatsiavut; and ii) a systematic and standardized survey on environment-health outcomes, piloted in Nunatsiavut communities and expanded to Nunavut. These components will be developed in close collaboration with partner communities and end-users to track and respond to cumulative environmental impacts on health outcomes from climate change, resource extraction, contaminants, and related socio-economic impacts.