Strontium, neodymium and lead isotopic signatures were measured on the carbonate-free lithogenic fraction of a suite of terrestrial and marine sediments from the North American Southwest. We present radiogenic isotope data from 1) surface sediments from nine different playa lakes in the Mojave Desert, 2) Late Quaternary silt mantles which drape the bedrock of Anacapa and San Clemente Islands offshore California and 3) fluvially-derived and hemipelagic sedimentary horizons in Late Quaternary age marine sediments from Ocean Drilling Project sites 893 and 1015 in the California Borderland Basins. We also present a compilation of measurements of bedrock Sr, Nd and Pb isotopic composition across the North American Southwest from the published literature. These datasets allow us to identify the isotopic signature of aeolian material exported from the North American Southwest and explore the contribution of dust to the California Borderland Basins.