Is high Se intake from marine diet during pregnancy and childhood neurotoxic or mitigating the adverse effects of MeHg exposure on child development?

All participants of the NCDS seen at the 5-year or the 11-year follow-ups are eligible for the proposed work. There is no data collection or field work related to the current research proposal. 1) 5--‐year follow--‐up: This study conducted as a follow-up of the Cord Blood Monitoring Program, which took place in Nunavik between 1993 and 1996. The following inclusion criteria were used for entry into the study: children between 4 and 6 years of age, biological mother as primary caretaker, full-term pregnancy, birth weight at least 2500 g, no known neurological or developmental disorder, and no severe chronic disease. Child testing was performed in Inuktituk and the outcomes documented were growth, vision and motor development. Socio-demographic and psychosocial confounders were documented through a maternal interview. A venous blood sample was obtained from each child. 2) 11--‐year follow--‐up: Inclusion criteria were: 8.5 yr ≤ child age ≤ 14.5 yr, birth weight ≥ 2.5 kg, gestation duration ≥ 35 weeks and the absence of either birth defects, neurological or health problems, or pervasive developmental disorders. During a five-year period (September 2005 to February 2010), 294 children and their mothers were enrolled and participated in neurocognitive assessments. Children were assessed with tests and instruments aimed at documenting physical growth, vision, intellectual function and cognitive development, behavioral development, heart rate and blood pressure. The mother was interviewed regarding demographic background, smoking, alcohol and drug use during pregnancy and whether the child was adopted. A venous blood sample was obtained from each child. 3) Biological measures: Biomarkers of MeHg and Se in cord, 5-year and 11-year blood samples are already available. Total Hg in cord blood and maternal hair was determined by cold vapor atomic absorption spectrometry (Pharmacia Model 120); cord blood Se, by inductively-coupled plasma mass spectrometry (ICP-MS); total Hg and Se in child blood by ICP-MS. Cord fatty acid profile, including DHA, was determined by capillary gas-liquid chromatography as described in Jacobson et al (Jacobson et al. 2008). Limits of detection (LODs) in cord blood were 0.2 μg/L, for total Hg and 7.9 μg/L for Se. LODs in child blood were 0.1 μg/L for total Hg, and 7.1 μg/L for Se. All laboratory analyses were performed at the Centre de toxicologie du Québec.

Identifier
Source https://www.polardata.ca/pdcsearch/PDCSearchDOI.jsp?doi_id=12644
Metadata Access http://www.polardata.ca/oai/provider?verb=GetRecord&metadataPrefix=fgdc&identifier=12644_fgdc
Provenance
Creator Muckle, Gina; Lemire, Mélanie; Ayotte, Pierre; Saint-Amour, Dave
Publisher Canadian Cryospheric Information Network
Contributor Polar Data Catalogue
Publication Year 2016
Rights Research programs, CCIN, or ArcticNet take no liability for the use or transmission of this data
OpenAccess true
Contact gina.muckle(at)crchul.ulaval.ca; pdc(at)uwaterloo.ca
Representation
Language English
Format Computer file
Discipline Environmental Research
Spatial Coverage (-64.000W, 55.000S, -64.000E, 55.000N)
Temporal Coverage Begin 2001-03-01T00:00:00Z
Temporal Coverage End 2009-12-31T00:00:00Z