Care–physical activity (care–PA) initiatives may improve participants’ lifestyles and thereby lower overweight and obesity rates. X-Fittt 2.0 is a two-year care–PA initiative specifically developed for citizens with a low socioeconomic status, consisting of 2 phases: 12 weeks of intensive guidance and sports sessions and 21 months of aftercare. Body measurements (1) and questionnaires (2) (taken at start and 3 months, 1 year and 2 years after the start) were used to study the impact of X-Fittt 2.0 on health, quality of life and societal participation using a mixed-methods design. (1) Body measurements included: Height, body weight, body mass index (BMI), fat percentage, waist circumference, blood pressure (2) Questionnaire included: Quality of life score and self-perceived health (EQ-5D-3L and EQ-VAS), illness and medicine use, visits to healthcare professionals, monitoring of physical activity, societal participation (USER-P), smoking and alcohol behaviour, demographic information